TABLE 4.

Tissue response score (Jessen et al., 2019)

Score	Definition	Description
0	Healed	Fibrocytes and collagen, multinucleated giant cells; capillaries; dense cellular connective tissue (dominant)
1	Mid-stage healing to healed	Capillaries; multinucleated giant cells; islands of loose matrix and dense collagen
2	Mid-stage healing	Macrophages (hemosiderin laden, cellular and substrate debris), fibroblasts, lymphocytes and admixture substrate (collagen and isolated fibrin fragments), multinucleated giant cells; admixture of neovascular buds and capillaries (dominant); loose cellular connective tissue
3	Early to mid-stage healing	Neovascular buds and capillaries; multinucleated giant cells; admixture of loose collagen (dominant) and fibrin
4	Early stage healing	Macrophages (erythrophagocytosis, cellular and substrate debris phagocytosis), fibroblasts, neutrophils, eosinophils, lymphocytes, multinucleated giant cells, plasma cells; neovascular buds; granulation tissue; admixture of fibrin and loose collagen
5	Residual blood to early stage healing	Neovascular buds; admixture of fibrin (dominant) and loose collagen
6	Residual blood	Cells and fibrin/protein; no vasculature; fibrin, no collagen