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. 2020 Jul 17;11:406. doi: 10.3389/fendo.2020.00406

Figure 1.

Figure 1

The role of natural killer cells in the pathogenesis of Graves' disease. (A) Enumeration of activating/inhibitory receptors and cytokines receptors, whose signals determined NK cells activity in health and disease. CD, cluster of differentiation; CD16, Fc receptor; CD244, non MHC biding receptor acting as costimulatory ligand for NK cells; CD69, early expressed after NK cell activation; CD96, interacts with nectin and nectin-like proteins; CD161, recognizes the human NKR-P1A antigen; KIR, killer cell immunoglobulin like receptor; LAG1 and LAG3, lymphocyte activation gene 1 and 3; NKp30, NKp44, NKp46, the natural cytotoxic receptors (NCR); NKG2A and NKG2D, natural killer group 2A and 2D; TIGIT, T cell immunoglobulin and ITIM domain; IL (interleukin)-21/18/15/10/12/4/2 R (receptor); TGF-bR, TGF beta receptor family; PD1, programmed cell death protein 1; TIM2, T-cell immunoglobulin and mucin-containing domain 2; (B) Several factors including microenvironment, cytokines milieu, epigenetic background and hyperthyroidism itself might impair NK protective activity. DC, dendritic cells; NK, natural killer cells.