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. 2020 Jul 17;10:1039. doi: 10.3389/fonc.2020.01039

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Copyright © 2020 Sarabia-Sánchez, Alvarado-Ortiz, Toledo-Guzman, García-Carrancá and Ortiz-Sánchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The AKT activity is present in upstream β-catenin/ALDH axis. (A) Representative image of spheres size upon 0.1–2.0 μM AZD-5363 treatment. (B–E) Western Blot analysis of active β-catenin, p-GSK3-β Ser9, and ALDH protein from spheres treated with 0.1–2.0 μM AZD-5363, the bar graphs shown the comparation of control (DMSO) vs. 2.0 μM AZD-5363 treatment from 3 independent experiments (Means ± S.E.M.), *p < 0.05,***p < 0.001. (F) Density plots showing the percentage of ALDH^HIGH cells in spheres treated with control (DMSO) or 2.0 μM AZD-5363 treatment for 72 h. (G) The bar graph shown the percentage of ALDEFLUOR positive cells in both conditions, DMSO and AZD-5363 treatment, considering 3 independent experiments (Means ± S.E.M.), *p < 0.05.