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. 2020 Jul 17;11:1077. doi: 10.3389/fphar.2020.01077

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Copyright © 2020 Wang, Zhang, Lu, Wang, Li, Yang, Li and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of phillyrin on attenuating fibrosis detected by pathology and morphology. (A) Preparation of the hearts from the sham group, model group, phillyrin group, and enalapril group. (B) The heart/weight index was calculated by dividing the heart weight with the body weight. (C) Hematoxylin–eosin staining in each group 30 days after the surgery (magnification ×200). Scale bars, 50 μM. (D) Collagen was evaluated using Masson’s trichrome staining images and the collagen volume fraction (CVF) (magnification ×400). Scale bars, 50 μM. ^## P < 0.01 or ^### P < 0.001 versus the sham group; ^* P < 0.05 or ^** P < 0.01 or ^*** P < 0.001 versus the model group.