Table 1.
Mean pharmacokinetic parameters calculated from equine drug plasma concentrations of harpagoside in six horses after single intragastric administration of Harpagophytum procumbens extract FB 8858 corresponding to 5 mg/kg BM versus 10 mg/kg BM harpagoside by PKSolver using a noncompartmental analysis of plasma data after extravascular administration. Linear trapezoidal calculation method was used for AUC
| Parameter | Unit | 5 mg/kg BM harpagoside (trial 1) | 10 mg/kg BM harpagoside (trial 2) |
|---|---|---|---|
| λz | 1/hr | 0.27 | 0.30 |
| t 1/2 | hr | 2.53 | 2.32 |
| t max | hr | 1 | 1 |
| C max | ng/ml | 25.59 | 55.46 |
| C last_obs/C max | 0.03 | 0.03 | |
| AUC0–t | ng hr ml−1 | 67.24 | 113.12 |
| AUC0–inf_obs | ng hr ml−1 | 70.46 | 117.85 |
| AUC0–t/0–inf_obs | 0.95 | 0.96 | |
| AUMC0–inf_obs | ng h2 ml−1 | 186.89 | 258.35 |
| MRT0–inf_obs | hr | 2.65 | 2.19 |
| V z/F_obs | L/kg | 259.04 | 283.83 |
| CL/F_obs | L hr−1 kg−1 | 70.96 | 84.86 |
AUC0–inf, Area under the plasma concentration‐time curve from time zero to infinity; AUC0–t, Area under the plasma concentration‐time curve from time zero to time t; AUMC0–inf, Area under the first moment of the plasma concentration‐time curve from time zero to infinity; CL/F, apparent total clearance of the drug from plasma after extravascular administration; C max, maximum plasma drug concentration; MRT, mean residence time from time zero to infinity; t max, time to maximum plasma concentration; V z/F, apparent volume of distribution during terminal phase after extravascular administration; λz, terminal rate constant; t 1/2, half‐life.