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. 2018 Oct 9;29(1):97–113. doi: 10.1111/bpa.12640

Figure 4.

Figure 4

Downregulation of NDUFB8 and COX1 expression levels in patient Purkinje cells in the cerebellum. Representative images of immunofluorescent labeling of respiratory chain proteins NDUFB8, COXI and porin in Purkinje cells provide evidence of reduced NDUFB8 and COX1 expression despite intact mitochondria density (porin) in patient tissues A. Scale bar = 100 microns. Quantitation of the protein abundance provides mitochondrial respiratory chain profiles for each individual patient given as the percentage of complex I (NDUFB8; B.i, unpaired t‐test, P = 0.0002) and IV (COX1; B.ii, unpaired t‐test, P < 0.0064) expression in Purkinje cells.