Table 1.
The immunogenicity of individual epitopes differs as demonstrated by analyzing the epitope specificity of donor specific antibody (DSA) developed in previously nonsensitized males, who returned on the waiting list after failure of their first kidney transplant
| Positions + amino acids | Yes DSA | No DSA | % DSA | Donor mismatches |
|---|---|---|---|---|
| 79G 80T 81L | 30 | 23 | 56.6 | A23 A24 A25 A32 |
| 11A 12M 13S | 55 | 49 | 52.9 | B7 B18 B27 B37 B38 B39 B46 B48 B61 |
| 150A 151H 152V | 104 | 95 | 52.3 | A1 A3 A11 A23 A25 A26 A29 A30 A31 A32 A33 |
| 126L 127K 128E | 102 | 94 | 52 | A1 A3 A11 A25 A26 A29 A30 A31 A32 A33 |
| 130L 131S 132S | 30 | 30 | 50 | B7 B8 |
| 73I 74D 75R | 14 | 47 | 23 | A31 A3375 |
| 73R 76E 77D | 20 | 69 | 22.5 | B27, B37, B47 |
| 185P 186R 187T | 1 | 15 | 6.3 | A33 |
Very immunogenic epitopes are associated with specific antibodies in more than 50% of the cases at risk whereas other epitopes are less immunogenic.