Table 4.
Cox proportional hazards models for the development of invasive infections and mortality
| Risk factor | Invasive infections | Mortality | ||
|---|---|---|---|---|
| HR* (95% CI) | p value | HR* (95% CI) | p value | |
| Disease | ||||
| MM | 1 | 1 | ||
| MDS | 1.6 (0.8‐3.3) | 0.2 | 1.1 (0.1‐8.7) | 1 |
| AML | 1.4 (0.8‐2.5) | 0.3 | 2.6 (0.6‐11.4) | 0.2 |
| Other | 1.4 (0.8‐2.5) | 0.3 | 2.6 (0.6‐11.7) | 0.2 |
| WHO | ||||
| 0 | 1 | 1 | ||
| 1 | 1.5 (1.0‐2.3) | 0.06 | 2.2 (1.0‐4.9) | 0.05 |
| ≥2 | 2.6 (1.7‐3.9) | <0.001 | 5.1 (2.1‐12.3) | <0.001 |
| HCT‐CI | ||||
| 0 | 1 | 1 | ||
| 1 | 1.0 (0.63‐1.5) | 0.9 | 1.7 (0.7‐4.1) | 0.3 |
| ≥2 | 1.3 (0.9‐1.8) | 0.16 | 2.4 (1.2‐5.2) | 0.02 |
| Infection† | ||||
| No | 1 | |||
| Yes | 5.8 (2.5‐13.0) | <0.001 | ||
*
HRs for the outcomes invasive infections and mortality were estimated in multivariable Cox models stratified for differences between centers.
†
Infection was included as a time‐dependent covariate into the Cox model for death. Its value switched from “no” to “yes” at the moment of onset of infection and remained “yes” afterward.