Figure 6.

Modulation of transcriptional bursts. Increasing the activator concentration leads to more frequent cycling of activators in the C‐space, with the distribution of residence time unaffected. The residence times shape the occurrence of transcription initiation events, thereby controlling the time series of mRNA number. As a result, the burst frequency, rather than burst size, is subject to modulation by activator concentration. Note that the bursting with high frequency makes it hard to differentiate between two successive bursts.