Table 3.

Overview of the data extracted from the meta‐analysis and the trial sequential analysis (TSA) on the experiments in the Plaque Index scores separated per main reported ingredient

Source					Outcomes				Heterogeneity		Trial sequential analysis (TSA)				Details see Appendixc
Index	Dentifrice slurry	# Studies	# exp in MA	Model	DiffM	95% CI	p‐valueb	95% Prediction interval	I 2 [95% CI]	P‐valueb	# participants in exp	Heterogeneity‐adjusted information size (TSA)	Maximum additional participants required	Statistical evidence (TSA)
TQ&H d Overall		5	13	Random	−0.30	−0.38; −0.22	<0.01	[−0.58; −0.02]	87% [79%;92%]	<0.01	377	338	0	Conclusive	S4, S7‐1
Sodium Fluoride		2	3	Randoma	−0.30	−0.33; −0.26	<0.01	[−0.52; −0.07]	0% [0%;89%]	0.38	104	338	234	Inconclusive	S4
Monofluorophosphate		2	3	Random	−0.14	−0.23; −0.04	<0.01	[−1.10; 0.82]	49% [0%;85%]	0.14	104	1007	903	Inconclusive	S4
Triclosan		4	5	Random	−0.44	−0.57; −0.32	<0.01	[−0.82; −0.06]	70% [23%;88%]	0.01	130	338	208	Inconclusive	S4
Greene & Vermillion e Overall		2	11	Random	−0.25	−0.32; −0.18	<0.01	[−0.34; −0.17]	0% [0%;0%]	1.00	280	51	0	Conclusive	S5, S7‐2
Sodium Fluoride		2	2	Randoma	−0.24	−0.41; −0.07	<0.01	[NA]	0% [NA]	0.55	50	50	0	Conclusive	S5
Monofluorophosphate		1	3	Randoma	−0.24	−0.35; −0.12	<0.01	[−0.98; 0.50]	0% [0%;23%]	0.87	60	28	0	Conclusive	S5
Stannous Fluoride		2	4	Randoma	−0.26	−0.40; −0.13	<0.01	[−0.56; 0.04]	0% [0%;0%]	0.97	110	61	0	Conclusive	S5
Triclosan		1	2	Randoma	−0.30	−0.56; −0.05	0.02	[NA]	0% [NA]	0.91	60	91	31	Inconclusive	S5
Plaque Area f Overall		5	19	Random	−0.30	−0.38; −0.23	<0.01	[−0.51; −0.09]	64% [41%;78%]	<0.01	558	82	NA	Inconclusive	S6, S7‐3
Sodium Fluoride		4	5	Randoma	−0.35	−0.39; −0.31	<0.01	[−0.41; −0.29]	0% [0%;65%]	0.67	154	82	0	Conclusive	S6
Monofluorophosphate		3	6	Random	−0.20	−0.31; −0.08	<0.01	[−0.44; 0.05]	20% [0%;65%]	0.28	164	112	NA	Inconclusive	S6
Stannous Fluoride		2	4	Randoma	−0.06	−0.35;0.23	0.69	[−0.69; 0.57]	0% [0%;0%]	1.00	110	112	NA	Inconclusive	S6
Triclosan		3	4	Randoma	−0.47	−0.51; −0.43	<0.01	[−0.56;−0.38]	0% [0%;77%]	0.57	130	112	0	Conclusive	S6

CI, Confidence interval; NA, Not applicable.

^aSame values with fixed model.

^bThe number of decimals to which the annotations have been rounded off is 2.

^cForest and funnel plots.

^dQuigley and Hein (Q&H) Plaque Index25 by Turesky et al.26

^eGreene and Vermillion Plaque Index.24

^fPlaque Area Index by Addy et al.15.