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. 2018 Dec 26;67(1):21–28. doi: 10.1111/jgs.15655

Table 1.

Selected PCORI Studies That Focus on the Needs of Older Adults

Variable Falls Prevention Depression Asthma Care Hospital Use

Study title

(PI name)

 Randomized Trial of a Multifactorial Fall Injury Prevention Strategy: A Joint Initiative of PCORI and the National Institute on Aging (Shalender Bhasin, MD) Optimizing Outcomes in Treatment‐Resistant Depression in Older Adults (Eric Lenze, MD) Clinic‐Based vs. Home‐Based Support to Improve Care and Outcomes for Older Asthmatics (Alex Federman, MD, MPH) An Emergency Department‐to‐Home Intervention to Improve Quality of Life and Reduce Hospital Use (Donna Carden, MD)
Study IDa 1‐A 1‐B 1‐C 1‐D
Study purpose To compare a multifactorial fall injury prevention intervention with enhanced usual care for reducing the risk of serious fall injuries among noninstitutionalized older adults. To compare the benefits and risks of different antidepressant strategies (augmentation and switching drugs) among older adults. To compare a clinic‐based asthma care coach with a home‐based community health worker coach with usual care for improving asthma‐related outcomes among older adults. To compare use of trained community‐based patient advocates with usual post‐ED care for improving outcomes after ED discharge.

Study

population

 Community‐living persons ≥75 y who are at increased risk for serious fall injuries Adults ≥60 y with major depressive disorder resistant to two or more antidepressant trials African American or Hispanic/Latino adults ≥60 y who have poorly controlled asthma Medicare fee‐for‐service beneficiaries with one or more chronic conditions
Interventions

Multifactorial fall injury prevention intervention: risk assessments, individualized fall care plans that address identified risk factors, and ongoing monitoring.

Enhanced usual care: patients discuss booklet on falls with primary care provider.

Step 1 strategies:

ADM + aripiprazole (augmentation),

ADM + bupropion (augmentation),

or switch from ADM to bupropion.

Participants resistant to step 1 will be randomized to step 2:

augment with lithium

or switch to nortriptyline.

Routine PCP care + a community health worker work to support and coordinate patient care in their home.

Routine PCP care + an asthma care coach for patient care in clinic.

Usual care: routine PCP care without any additional care coordination or support provided.

ED‐to‐home transition intervention: home visit and telephone calls with a trained, community‐based patient advocate who will help patients to attend follow‐up physician visits, respond to signs of worsening disease, address medication concerns, and communicate with healthcare providers.
Out comes Serious falls, fall injuries, concerns about falling, physical function and disability, anxiety/depressive symptoms, hospitalizations, nursing home admissions, and death Psychological well‐being, remission from depression, serious adverse events, falls and fall‐related injuries, physical function, and social participation Asthma control, quality of life, resource use, medication adherence, self‐management behaviors, ability to conduct daily activities, and patient and caregiver satisfaction with care

Health‐related quality of life (health status, satisfaction with care, physical function, and social and emotional health), ED visits, hospital admissions, ability of patients to make decisions about their health and healthcare

Abbreviations: ADM, antidepressant medication; ED, emergency department; ID, identification; PCORI, Patient‐Centered Outcomes Research Institute; PCP, primary care provider; PI, principal investigator.

a

The study ID is a code that appears next to text that refers to an example study described in a table. It enables the reader to find the detailed information to which the body of the text refers.Study 1‐A is available at https://www.pcori.org/research‐results/2014/preventing‐serious‐falls‐among‐older‐adults‐project‐supported‐pcori‐and; study 1‐B is available at