Table 2.
Criteria for assessment of skin adverse reactionsa
| Score | Appearance of erythemab | Formation of edemab | Skin desquamationc |
|---|---|---|---|
| 0 | None | None | None |
| 1 | Very mild erythema | Very mild edema (almost imperceptible) | Dryness |
| 2 | Well‐defined erythema | Mild edema (defined area, beginning of swelling) | Thin scales |
| 3 | Moderate erythema | Moderate edema (swelling of ~1 mm) | Moderate scales |
| 4 | Severe erythema | Intense edema (growth >1 mm and beyond the application area) | Large scales |
a
The sum of the scores for each category was used to classify the reaction intensity as follows: 0‐2, No reaction/equivocal; 3‐4, Mild reaction; 5‐8, Moderate reaction; >8, Intense reaction.
b
Scale according to Draize et al.11
c
Adapted from the Kligman scale that scores skin desquamation on a scale of 1‐3.