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Phenotypic conversion in different types of macrophages. M0 macrophages can polarize to M1 or M2 (M2a, M2b, M2c) in response to different inducers. M2b macrophages can convert to the other subtypes of M2 macrophages in response to different stimuli. Notably, M2b macrophages inhibit the conversion from M0 to M1. Moreover, M2b cannot repolarize to M1 during exposure to M1 inducer
