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. 2020 Jul 24;20:340. doi: 10.1186/s12935-020-01425-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Knockdown of KCNQ1OT1 suppressed CRC cell proliferation, migration, invasion and promoted cell apoptosis. a The expression of KCNQ1OT1 was detected by qRT-PCR in SW480 and LS1034 cells by transfecting with specific siRNAs. b, c Proliferative ability of SW480 and LS1034 cells transfected with si-KCNQ1OT1#1 or si-KCNQ1OT1#2 was examined by MTT assay. d, e The cell cycle analysis of SW480 and LS1034 cells was detected by flow cytometry. f The cellular apoptosis of SW480 and LS1034 cells was tested by flow cytometry. g, h The migration and invasion of SW480 and LS1034 cells after transfected with si-KCNQ1OT1 were revealed by Transwell assays. i, j The protein levels of EMT markers (E-cadherin, MMP9), CyclinD1, apoptosis-associated proteins (Bcl-2, Cleaved-casp-3) were measured by western blot assays. *P < 0.05, vs. control group