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. 2020 Jul 23;51:94. doi: 10.1186/s13567-020-00820-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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The comparison of the amounts of individual metabolites presented in homogenate and cultivation medium of male (M) and female (F) ofH. contortusadults after 12 h incubation in 10 µM ABZ concentration with prior 18 h pre-incubation with ABZ at 0.01, 0.1 and 1.0 µM concentrations or without. Individual metabolites: M1 and M2 (N-glycoside of ABZSO; A, B, M3 (ABZSO; C), M4 (N-glycoside of hydrolyzed ABZ; D), M6 (ABZ-sulfone; E), M7, M8 and M9 (N-glycoside of ABZ; F–H), M10–M13 (acetylglycoside of ABZ; I–L). The data represent the mean ± S.D. (n = 3). An asterisk (*) indicates a significant difference (P < 0.05) compared to pre-incubation without ABZ concentration. n.d. = not detected.

The comparison of the amounts of individual metabolites presented in homogenate and cultivation medium of male (M) and female (F) ofH. contortusadults after 12 h incubation in 10 µM ABZ concentration with prior 18 h pre-incubation with ABZ at 0.01, 0.1 and 1.0 µM concentrations or without. Individual metabolites: M1 and M2 (N-glycoside of ABZSO; A, B, M3 (ABZSO; C), M4 (N-glycoside of hydrolyzed ABZ; D), M6 (ABZ-sulfone; E), M7, M8 and M9 (N-glycoside of ABZ; F–H), M10–M13 (acetylglycoside of ABZ; I–L). The data represent the mean ± S.D. (n = 3). An asterisk (*) indicates a significant difference (P < 0.05) compared to pre-incubation without ABZ concentration. n.d. = not detected.