Table 5.

Adverse events

	Grade1	Grade2	Grade3	Grade4	All grade	Grade ≥ 3
Total	38 (83%)	18 (39%)	7 (15%)	–	41 (89%)	7 (15%)
Hematologic
Neutropenia	5	4	1	–	10 (22%)	1 (2%)
Leukocytopenia	7	6	–	–	13 (28%)	–
Anemia	13	5	2	–	20 (43%)	2 (4%)
Thrombocytopenia	6	2	–	–	8 (17%)	–
Gastrointestinal
Nausea	9	2	1	–	13 (26%)	1 (2%)
Vomiting	2	0	1	–	3 (7%)	1 (2%)
Anorexia	5	4	2	–	11 (24%)	2 (4%)
Diarrhea	4	5	2	–	11 (24%)	2 (4%)
Abdominal pain	–	–	1	–	1 (2%)	1 (2%)
Others
Total bilirubin elevation	4	–	–	–	4 (9%)	–
AST elevation	2	–	–	–	2 (4%)	–
ALT elevation	1	–	–	–	1 (2%)	–
Creatinine elevation	1	1	–	–	2 (4%)	–
Aphthous stomatitis	3	2	–	–	5 (11%)	–
Fatigue	11	7	–	–	18 (39%)	–
Pigmentation	11	–	–	–	11 (24%)	–
Rash	3	3	–	–	6 (13%)	–
Chest pain	–	1	–	–	1 (2%)	–

Abbreviations: AST aspartate aminotransferase, ALT alanine aminotransferase