Table 2.

1-Year weight loss and secondary efficacy of currently available antiobesity drugs.

Drug	Weight loss relative to placebo	Glycemic measures	Blood pressure	Lipids
Orlistat	Approximately 3.0%	+++a	++	++
Lorcaserin	3.0 to 3.6%	+++	+	+
Liraglutide	4.0 to 5.4%	++++	++	++
Phentermine/Topiramate	8.6 to 9.3%	+++	++	++
Naltrexone/Bupropion	3.3 to 4.8%	++	Unfavorable	+

^a+ least efficacy; +++++ most efficacy.

When several doses have been studied, data are shown for the most effective dose.