FIGURE 1.

Enhancer adoption as a result of different structural variants (SV). Graphical overview of how different types of SV can lead to enhancer adoption mechanisms. In the control allele (A), Gene A and Gene B are located in two neighboring TADs. In (B–C), we illustrate how different genomic rearrangements, such as inversions (B), deletions (C), or duplications (D), can remodel the 3-D chromatin landscape (through processes, such as TAD shuffling, TAD fusion, or formation of a new TAD, respectively) and increase Gene B expression due to the regulatory effects of ectopic enhancers.