Figure 1.

Primary tumor growth following treatment with DaRT+polyIC^PEI. 4T1-bearing mice (40 mm³) were treated intratumorally with polyIC^PEI (20 μg/40 μl) or polyIC^naked (20 μg/40 μl) or vehicle, 72 and 24 h prior to the insertion of a single DaRT seed (length = 8 mm, activity = 70 kBq) or an inert seed (for 29 days). (A) Schematic representation of the treatment protocol. (B) CT image of a DaRT seed inside the tumor. (C) Representative primary tumors 29 days after tumor cell inoculation. (D) Mean tumor volumes ± SEM on the day of treatment start (0) and on the day of experiment termination (29). p_t−test < 0.005 for DaRT+ polyIC^PEI vs. control; p_t−test < 0.0005 for DaRT+ polyIC^PEI vs. DaRT alone; p_t−test < 0.0005 for DaRT+ polyIC^PEI vs. polyIC^PEI alone; p_t−test < 0.05 for DaRT+ polyIC^PEI vs. DaRT+polyIC^naked. (E) Individual tumor growth curves for each treatment, up to 29 days from treatment start. Each line represents an individual mouse. The results are based on cumulative data from two different experiments.