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. 2020 Jul 17;11:759. doi: 10.3389/fgene.2020.00759

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Copyright © 2020 de Pretis, Furlan and Pelizzola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of temporal RNA dynamics produced by INSPEcT-GUI in the “user defined” mode. When INSPEcT-GUI is run in the “user defined” mode, the impact of the RNA kinetic rates can be evaluated without the need of experimental data. Four examples are reported. (A) At steady-state constant RNA kinetic rates set the abundance of RNA species, according to Eq. (2) (see text). (B) Given a constant rate of synthesis, premature RNA is reduced over time due to an increase in the rate of RNA processing. (C) Given a constant rate of RNA processing, both premature and mature RNA species are increased over time due to an increase in the rate of RNA synthesis. (D) As in (C) but concomitant with an increase in the rate of RNA degradation. As a result, the contrasting modulation of synthesis and degradation rates levels the temporal profile of mature RNA.