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. 2020 Jul 17;11:1476. doi: 10.3389/fimmu.2020.01476

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Copyright © 2020 Moore, Huang, Jain, Chalmers, Macian and Putterman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the TCR repertoire between MRL/lpr and MRL/MpJ spleens. The TCR repertoires of MRL/lpr (n = 9) and MRL/MpJ (n = 5) spleens were analyzed. (A) Sample clonality. (B) Number of unique productive TCR clones. (C) Frequency of the top productive TCR clones. (D) Selective increased TCRB V gene usage in MRL/lpr spleen repertoires compared to MRL/MpJ. (E) Specific decreased TCRB V gene usage in MRL/lpr spleen repertoires compared to MRL/MpJ. Each dot indicates one mouse and bar graphs represent mean ± SD. P-values were determined with an unpaired T-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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