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. 2020 Jul 17;11:1476. doi: 10.3389/fimmu.2020.01476

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Copyright © 2020 Moore, Huang, Jain, Chalmers, Macian and Putterman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The choroid plexus exhibits distinct TCR profiles compared to other MRL/lpr tissues. (A) Frequency of CDR3 lengths compared to Gaussian distributions in MRL/lpr choroid plexus (left), salivary gland (middle), and spleen (right) TCR repertoires. (B) Selective increased TCRB V gene usage in MRL/lpr choroid plexus tissue. (C) Specific decreased TCRB V gene usage in MRL/lpr choroid plexus tissue. (D) Frequency of TCRB D (top) and J gene (bottom) usage in MRL/lpr tissues. P-values determined by one-way ANOVAs, *p < 0.05, **p < 0.01, ****p < 0.0001.

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