Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 17;45(2):119–140. doi: 10.1111/nan.12489

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Unchimerised mice implanted with GL‐261. (A) CD11b⁺/CD45⁺ cells were selected and gated against cell surface markers ordinarily used to characterise different immune populations: granulocytes, T and B‐cells and GAMM. An overlay of all four immune populations using CD11b/CD45 expression is shown (left overlay box). GAMM population was then selected (pink box) and each GAMM subpopulation back‐gated using CD11b/CD45. A second overlay demonstrates overlap of inflammatory monocytes, undifferentiated macrophages, differentiated macrophages and microglia, thereby showing that CD45 expression does not adequately separate microglia from other GAMM populations. (B) Relative proportions of each immune cell type. GAMM is the sum of inflammatory monocytes, undifferentiated macrophages, differentiated macrophages and microglia. (C) Relative proportions of each GAMM subpopulation.