Table 3.
Univariate and multivariate Cox regression models to determine risk factors for mortality or decompensation during follow‐up
| HR (95% CI) | P‐value | MV model 1a | MV model 1b | MV model 2a | MV model 2b | |
|---|---|---|---|---|---|---|
| HR (95%CI); P‐value | HR (95% CI); P‐value | HR (95% CI); P‐value | HR (95% CI); P‐value | |||
| Age | 1.025 (0.992–1.058) | 0.139 | NS | NS | NS | NS |
| CPS | B: 2.349 (1.07–5.15) | 0.033 | B: 2.08 (0.89–4.89); P = 0.092 | B: 2.31 (1.01–5.3); P = 0.048 | NS | NS |
| C: 6.65 (2.577–17.19) | <0.001 | C: 5.38 (1.89–15.32); P = 0.002 | C: 5.28 (1.89–14.71); P = 0.001 | NS | NS | |
| HCC | 2.079 (0.944–4.579) | 0.069 | NS | NS | NS | NS |
| MELD | 1.124 (1.045–1.209) | 0.002 | NS | NS | NS | NS |
| Bioavailable T < 1.59 ng/mL | 3.933 (1.54–10) | 0.004 | 2.59 (0.97–6.93); P = 0.059 | NS | 2.47 (0.93–6.57); P = 0.069 | NS |
| Total T < 6.25 ng/mL | 3.493 (1.757–6.942) | <0.001 | NS | 2.50 (1.21–5.16); P = 0.013 | NS | 3.07(1.52–6.17); P = 0.002 |
| PRL >13.8 ng/mL | 2.282 (1.14–4.56) | 0.020 | NS | NS | NS | NS |
| Creatinine | 1.924 (1.068–3.466) | 0.029 | NS | NS | NS | NS |
| Albumin | 0.910 (0.863–0.961) | 0.001 | NS | NS | 0.93(0.88–0.99); P = 0.036 | NS |
| Presence of ascites | 3.634 (1.918–6.884) | <0.001 | NS | NS | 2.28 (1.12–4.64); P = 0.023 | 3.15 (1.52–6.17); P = 0.001 |
| Previous hepatic decompensation | 1.815 (0.996–3.307) | 0.052 | NS | NS | NS | NS |
MV model 1a: Significant variables in the multivariate Cox regression model (included variables: Child–Pugh score [CPS], hepatocellular carcinoma [HCC], bioavailable testosterone [T], creatinine, and previous hepatic decompensation).
MV model 1b: Significant variables in the multivariate Cox regression model (included variables: CPS, HCC, total T, creatinine, and previous hepatic decompensation).
MV model 2a: Significant variables in the multivariate COX regression model (included variables: Model for End‐stage Liver Disease [MELD], HCC, bioavailable T, albumin, presence of ascites [yes/no], and previous hepatic decompensation).
MV model 2b: Significant variables in the multivariate Cox regression model (included variables: MELD, HCC, total T, albumin, presence of ascites [yes/no], and previous hepatic decompensation).
CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; MV, multivariate; NS, non significant (P > 0.1); PRL, prolactin.