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Receiver operating characteristic curves of the multivariate logistic regression model including percentage of free PSA to total PSA ratio (%fPSA), thrombospondin 1 (THBS1) and cathepsin D (CTSD) in the training (black line) and validation (red line) sets for predicting significant cancer (Gleason score ≥7) according to (A) biopsy Gleason score and (B) pathological Gleason score of the prostatectomy specimen.
