Table 3.
Impact of using percentage of free PSA to total PSA ratio (%fPSA) and the multivariate models of thrombospondin 1 + cathepsin D with and without %fPSA on negative biopsies avoided and any as well as significant cancers detected or missed
| Negative biopsies | Any cancer | Biopsy GS ≥7 | Prostatectomy GS ≥4 + 3 | |||||
|---|---|---|---|---|---|---|---|---|
| Performed, n | Avoided, n (%) | Detected, n (%) | Missed, n (%) | Detected, n (%) | Missed, n (%) | Detected, n (%) | Missed, n (%) | |
| Training | ||||||||
| Univariate | ||||||||
| %fPSA | 86 | 21 (20) | 117 (90) | 13 (10) | 48 (92) | 4 (8) | 20 (95) | 1 (5) |
| Multivariable | ||||||||
| THBS1 + CTSD | 48 | 59 (55) | 117 (90) | 13 (10) | 46 (88) | 6 (12) | 19 (90) | 2 (10) |
| %fPSA + THBS1 + CTSD | 50 | 57 (53) | 117 (90) | 13 (10) | 47 (90) | 5 (10) | 19 (90) | 2 (10) |
| Validation | ||||||||
| Univariate | ||||||||
| %fPSA | 98 | 31 (24) | 97 (90) | 11 (10) | 49 (91) | 5 (9) | 12 (100) | 0 (0) |
| Multivariable | ||||||||
| THBS1 + CTSD | 56 | 73 (57) | 97 (90) | 11 (10) | 48 (89) | 6 (11) | 12 (100) | 0 (0) |
| %fPSA + THBS1 + CTSD | 49 | 80 (62) | 97 (90) | 11 (10) | 47 (87) | 7 (13) | 11 (99) | 1 (8) |
%fPSA, percentage of PSA to total PSA ratio; CTSD, cathepsin D; GS, Gleason score; THBS1, thrombospondin 1.