Figure 6.

FIX activity in the one‐stage clotting assay by FIX concentrate at a FIX concentration of 0.05 IU mL ⁻¹: percentage of normal human plasma (NHP) FIX activity at a spiked concentration of 0.05 IU mL ⁻¹ measured with 12 different activated partial thromboplastin time (APTT) reagents in the one‐stage clotting assay for recombinant FIX–albumin fusion protein (rIX‐FP), recombinant FIX Fc fusion protein (rFIXFc), and recombinant FIX (rFIX). APTT reagents showing the greatest variability are indicated. Suboptimal accuracies were observed for TriniCLOT aPTT S, STA PTT and Dapttin TC for all products (data not shown). In each box, the middle horizontal line represents the median, and the lower and upper borders of the box represent the first and third quartiles. The whiskers indicate the minimum and maximum, and the ‘+’ sign indicates the arithmetic mean. CV, coefficient of variation.