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. 2018 Oct 22;71(1):57–65. doi: 10.1002/iub.1945

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© 2018 The Authors. IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Co‐expression of RC‐ODC and AZ suppressed tumorigenicity in vivo. (a) The gross morphology of the tumors from the four groups of six mice each is shown. (b) A significant difference in tumor volume was detected among the groups starting on the 19th day (P < 0.05). (c) Tumor tissues were subjected to immunostaining analysis of the KRAS protein, and the group co‐treated with RC‐ODC and AZ showed relatively weaker cytoplasmic expression of KRAS compared with the mock and control groups. The quantitative analysis of KRAS protein levels is also shown.