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. 2018 Jul 23;75(1):153–162. doi: 10.1111/biom.12940

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© 2018 The Authors. Biometrics published by Wiley Periodicals, Inc. on behalf of International Biometric Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Boxplot showing variation in biopsy offset (difference in time at which Gleason reclassification, also known as GR, is detected and the true time of GR, in months) for the simulated (500 datasets) test patients, across different schedules. Types of personalized schedules (full names in brackets): Exp. GR time (expected time of GR), Med. GR time (median time of GR), Dyn. risk GR (schedules based on dynamic risk of GR), hybrid (a hybrid approach between median time of GR and dynamic risk of GR). Annual corresponds to a schedule of yearly biopsies and PRIAS corresponds to biopsies as per PRIAS protocol.