Figure 5.

Architectural patterns which may be challenging for grading: (A) well‐defined grade 3 medium‐sized glands transitioning to and intermingling with increasingly smaller‐sized glands, but still considered as grade 3, contrasting with (B) medium‐sized grade 3 glands with an abrupt transition to a cluster of ill‐formed (grade 4) glands and (C) medium‐sized well‐described grade 3 glands slowly transitioning into a larger field (>10 structures) of ill‐formed (grade 4) glands. In (D) small‐sized closely packed circumscribed glands surrounded by thin wisps of stroma, most consistent with grade 3 glands, (E) well‐circumscribed pale glands with flocculated eosinophilic lumen content and considerable cytonuclear atypia (compared to gland on the right side) and (F) pseudo‐rosetting pattern in an otherwise solid carcinoma field in a biopsy considered as grade 5 pattern at the ISUP 2014 consensus meeting.