Table 3.
Genes with downregulation in BCC by microarray analysis. The curated list of DEGs include genes selected through GO analysis, literature mining and on the basis of overlapping with results from other studies of BCC molecular signatures16, 17, 18, 19, 20, 23
| The 25 most downregulated genes | Curated DEGs | ||||
|---|---|---|---|---|---|
| Gene symbol | FC | Log 2 FC | Gene symbol | FC | Log 2 FC |
| PLIN4 | –256·8 | –8·0 | ADH1A | –29·7 | –4·9 |
| DCD | –250·3 | –8·0 | PRLR | –27·1 | –4·8 |
| LEP | –177·8 | –7·5 | SOX21 | –26·5 | –4·7 |
| PLIN1 | –163·9 | –7·4 | WNT16 | –25·5 | –4·7 |
| PIP | –134·5 | –7·1 | RBP4 | –24·9 | –4·6 |
| TMEM213 | –75·9 | –6·2 | MUCL1 | –24·8 | –4·6 |
| CA6 | –73·3 | –6·2 | FABP7 | –23·7 | –4·6 |
| SERPINA12 | –72·9 | –6·2 | ADH1B | –23·4 | –4·5 |
| ADIPOQ | –63·3 | –6·0 | TUSC8 | –22·2 | –4·5 |
| GDPD2 | –62·2 | –6·0 | FOXA1 | –21·9 | –4·5 |
| MYOC | –62·1 | –6·0 | CDHR4 | –20·9 | –4·4 |
| PSAPL1 | –52·3 | –5·7 | CDHR4 | –20·9 | –4·4 |
| SCGB1D1 | –51·5 | –5·7 | FOXP2 | –20·7 | –4·4 |
| HOXA‐AS3 | –49·5 | –5·6 | NOX1 | –18·4 | –4·2 |
| FA2H | –46·1 | –5·5 | TIMP4 | –18·1 | –4·2 |
| ACADL | –42·9 | –5·4 | ADH1C | –17·1 | –4·1 |
| SCGB1D2 | –42·9 | –5·4 | LAMB4 | –17·0 | –4·1 |
| CDHR1 | –41·5 | –5·4 | LIPK | –16·7 | –4·1 |
| SOX6 | –41·1 | –5·4 | TNMD | –15·9 | –4·0 |
| FABP4 | –38·3 | –5·3 | WNT3 | –15·9 | –4·0 |
| CHP2 | –37·9 | –5·2 | COBL | –14·5 | –3·9 |
| ISL1 | –37·5 | –5·2 | SPINK1 | –12·4 | –3·6 |
| MRAP | –36·9 | –5·2 | CLDN10 | –12·0 | –3·6 |
| CLDN3 | –36·8 | –5·2 | LIPE | –12·0 | –3·6 |
| HOXA9 | –36·7 | –5·2 | SLC2A4 | –11·9 | –3·6 |
| LIPH | –11·4 | –3·5 | |||
| ENDOU | –11·4 | –3·5 | |||
| EXPH5 | –11·1 | –3·5 | |||
| ERBB4 | –10·0 | –3·3 | |||
| AZGP1 | –9·5 | –3·2 | |||
| FCGBP | –9·3 | –3·2 | |||
| DMKN | –9·2 | –3·2 | |||
| ZBTB16 | –8·2 | –3·0 | |||
| TGFBR3 | –7·7 | –2·9 | |||
| GPR126 | –7·6 | –2·9 | |||
| AKR1C1 | –7·5 | –2·9 | |||
| CA12 | –7·4 | –2·9 | |||
| ABCC3 | –7·3 | –2·9 | |||
| NRG2 | –6·8 | –2·8 | |||
| C2CD2 | –6·6 | –2·7 | |||
| SLC25A48 | –6·1 | –2·6 | |||
| NRG4 | –6·1 | –2·6 | |||
| WNT4 | –5·9 | –2·6 | |||
| CRYAB | –5·9 | –2·6 | |||
| LPL | –5·2 | –2·4 | |||
BCC, basal cell carcinoma; DEGs, differentially expressed genes; FC, fold change; GO, Gene Ontology.