Lack of clinical efficacy and safety evidence of biologics in patients <6 years |
Limited availability of non‐steroid‐based alternative therapies |
Lack of available therapies for children with severe asthma |
Difficult diagnosis in children |
Scarcity of studies on allergen immunotherapy in children |
Limited access to specialist pediatric asthma care in some countries |
No uniform definition of pediatric asthma or pediatric asthma control |
Inadequate pediatric focus in current clinical practice guidelines |
Lack of data on asthma endotypes/phenotypes |
Lack of well‐defined pediatric treatable traits |
Lack of molecular studies |
Lack of data on personalized treatment strategies based on a phenotype (endotype) approach |
Lack of treatment options for comorbidities |