TABLE 1.
Polymorphic integrated HERV-K (HML-2) and diseases.
| Locus | Coordinate in hg19 | Alleles* | Relevance to diseases | References |
| HERV-K113 | Chr19: 21841535–21841541 | Pro/pre | Higher frequency in Sjogren’s syndrome, MS, SLE, and RA | Moyes et al., 2005; Krzysztalowska-Wawrzyniak et al., 2011 |
| 1p13.2 | Chr1: 111802591–111802597 | Solo/pre | Higher frequency in Lung adenocarcinoma | Kahyo et al., 2013 |
| 5q14.1 | Chr5: 80442265–80442271 | Solo/pre | Higher frequency among individuals with strong addictive behavior, LTR insertion can modulate RASGRF2 transcription | Karamitros et al., 2018 |
| HERV-K115 | Chr8: 7355396–7364859 | Pro/pre | No significant increase frequency in breast cancer, schizophrenia, Sjogren’s syndrome, and MS patients | Burmeister et al., 2004; Moyes et al., 2005; Otowa et al., 2006 |
| HERV-K113 | Chr19: 21841535–21841541 | Pro/pre | No significant difference in the prevalence of | Burmeister et al., 2004 |
| 1p31.1 | Chr1: 75842770–75849143 | Pro/pre | proviruses between breast cancer patients | Wildschutte et al., 2014 |
| 3q13.2 | Chr3; 112743478–112752282 | Pro/solo/pre | and controls | |
| 6q14.1 | Chr6: 78427018–78436083 | Pro/solo | ||
| 7p22.1 | Chr7: 4630560–4640031 | Pro/solo/pre/tandem | ||
| 8p23.1 | Chr8: 8054699–8055725 | Pro/pre | ||
| 10p12.1 | Chr10: 27182398–27183380 | Pro/solo | ||
| 11q22.1 | Chr11: 101565793–101575259 | Pro/solo/pre | ||
| 12q13.2 | Chr12: 55727213–55728183 | Pro/solo/pre | ||
| 12q14.1 | Chr12: 58721241–58730698 | Pro/solo | ||
| 19p12 | Chr19:21841535–21841541 | Pro/pre |
*pro, provirus integration; solo, solo-LTR integration; pre, pre-integration.