TABLE 3.
Levels of pro-inflammatory cytokines and their correlations with tuberculosis disease severity.
| Cytokines (LOD) | HIV–LTBI+ Median (ranges): pg/ml | HIV–PTB+ Median (ranges): pg/ml | P-value of HIV–LTBI versus HIV–PTB | P-value of non-severe versus severe HIV–PTB | Correlation with Gal-9 r(p) | Correlation with OPN r(p) |
| IL-6 (0.34 pg/ml) | 20.97 (3.54–46.48) | 156.6 (23.5–864.9) | <0.0001 | 0.044 | 0.3774 (0.0504) | 0.3985 (0.0409) |
| IL-8 (0.36 pg/ml) | 56.34 (50–190.25) | 283.7 (50–431.9) | 0.0001 | 0.25 | 0.4289 (0.0296) | 0.40 (0.03) |
| IL-10 (0.69 pg/ml) | 6.01 (3.57–8.51) | 11.96 (6.43–992.3) | <0.0001 | 0.2 | 0.2426 (0.1514) | 0.1522 (0.2609) |
| IFN-γ (1.05 pg/ml) | 800 (800–1463.8) | 4214 (800–5458) | <0.0001 | 0.96 | 0.2549 (0.1391) | 0.1435 (0.2731) |
| IP-10 (1.43 pg/ml) | 3562.59 (400–9862.29) | 19273 (5598–42326) | <0.0001 | 0.83 | 0.4211 (0.0322) | 0.3308 (0.0771) |
| TNF-α (1.13 pg/ml) | Below detection limit | 20 (20–534.9) | Not obtained | 0.27 | 0.1844 (0.2183) | 0.186 (0.2162) |
LOD, limit of detection.