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Huh7 human cells treated with 400 μM palmitate and 4.5 g/L glucose (HFHG) show accumulation of p62/SQSTM1 protein and increase of LC3-II/LC3-I protein ratio (A) as well as up-regulation of inflammatory cytokines (B) and lysosomal mass (C) after 72 and 96 h of treatment. TOM20 was used as loading control. Densitometric analyses of p62/SQSTM1 and LC3-II/LC3-I are shown in the bottom panel (A). n = 3; ***p < 0.001, *p < 0.05 vs. Ctr; °°°p < 0.001 vs. HFHG 72 h, ###p < 0.001 vs. Ctr 96 h.
