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p62/SQSTM1 accumulates with NAFLD progression (A–C). P62/SQSTM1 positive Mallory-Denk bodies (arrowheads) were individuated in hepatocytes. Double labeling experiments with a lysosome marker (LAMP1, red) and autophagy impairment marker (p62/SQSTM1 green), confirmed that p62/SQSTM1 accumulates outside the lysosomes (D). n = 59. Scale bar: 25 μm; * = p < 0,05 vs. NAS 0–2 or mild fibrosis.
