Table 1.

Randomized clinical trial: paracetamol vs. active drug (ibuprofen or indomethacin).

References	Drug	Administration	Dosage	N	% total closure rate	Serum level	Hepatotoxicity
Dang et al. (13)	Paracetamol	Oral	15 mg/kg/6 h	80	81.2	No	No
	Ibuprofen	Oral	10–5–5 mg/kg	80	78.8	No	No
Oncel et al. (14)	Paracetamol	Oral	15 mg/kg/6 h	40	96.6	No	No
	Ibuprofen	Oral	10–5–5 mg/kg	40	93.6	No	No
El-Mashad et al. (30)	Paracetamol	IV	15 mg/kg/6 h	100	88	No	No
	Ibuprofen	IV	10–5–5 mg/kg	100	83	No	No
	Indomethacin	IV	10–5–5 mg/kg	100	87	No	No
Bagheri et al. (7)	Paracetamol	Oral	15 mg/kg/6 h	67	91	No	No
	Ibuprofen	oral	20–10–10 mg/kg	62	90.3	No	No
Yang et al. (27)	Paracetamol	Oral	15 mg/kg/6 h	44	70.5	No	No
	Ibuprofen	Oral	10–5–5 mg/kg	43	76.7	No	No
Dash et al. (28)	Paracetamol	Oral	15 mg/kg/6 h	38	100	No	No
	Indomethacin	IV	0.2 mg/kg/ 24 h	39	94.6	No	No
Al-lawama et al. (29)	Paracetamol	Oral	10 mg/kg/6 h	13	92	No	No
	Ibuprofen	Oral	10 mg/kg/24 h	9	89	No	No
Kumar et al. (31)	Paracetamol	Oral	15 mg/kg/6 h	81	78	No	No
	Ibuprofen	Oral	10–5–5 mg/kg	80	81	No	No