Table 4.
Hydrogen bonding partners of PLP in D-serine dehydratase (DSD), deaminase (TDH), L-serine dehydratase from E. coli and human liver (LSD), tryptophan synthase (β-subunit) (TPS), O-acetylserine sulfhydrylase (OASS), cystathionine β-synthase (CBS), serine racemase (SR).
| Enzyme | DSD | TDH | LDH | TPS | OASS | CBS | SR |
|---|---|---|---|---|---|---|---|
| Total number of amino acids per subunit | 442 | 494 | 327 | 391 | 315 | 435 | 340 |
| PLP-phosphate group | G282 | G191 | G171 | S235 | T180 | T260 | G185 |
| G281 | G190 | G170 | G234 | G178 | G268 | G186 | |
| G279 | G188 | G168 | G232 | G176 | G256 | G187 | |
| V280 | G189 | G169 | G233 | T177 | G257 | G188 | |
| O3 ligand | N170 | N89 | N67 | N71 | N149 | N86 | |
| N1 ligand | T424 | T315 | C303 | S377 | S272 | S349 | S308 |
| SB ligand | K118 | K62 | K41 | K87 | K41 | K119 | K57 |