Table 2.
Incidence of abnormal liver biochemical indicator: results of meta-analyses
| Groups | No. studies | Range (%) | Pooled proportion using random-effects model | Heterogeneity | Publication bias | |
|---|---|---|---|---|---|---|
| I2 | p | Egger:bias | ||||
| Any abnormal liver biochemical indicator at admission | 12 | 0–61.1 | 0.272 (95% CI, 0.190–0.363) | 88.6% (95% CI, 82.3–92%) | < 0.0001 | 4.611 (95% CI, – 0.262 to 9.483) |
| p = 0.0612 | ||||||
| Abnormal ALT at admission | 28 | 7.5–55.2 | 0.204 (95% CI, 0.168–0.243) | 88% (95% CI, 84.1–90.5%) | < 0.0001 | 2.650 (95% CI, 0.505–4.795) |
| p = 0.0174 | ||||||
| Abnormal AST at admission | 28 | 7–61.1 | 0.218 (95% CI, 0.176–0.263) | 89.3% (95% CI, 86.2–91.5%) | < 0.0001 | 2.890 (95% CI, 0.740–5.039) |
| p = 0.0104 | ||||||
| Abnormal ALP at admission | 4 | 1.2–13.7 | 0.047 (95% CI, 0.018–0.089) | 81.6% (95% CI, 28.9–91.1%) | 0.001 | 2.7486 (95% CI, – 1.591 to 7.088) |
| p = 0.1124 | ||||||
| Abnormal GGT at admission | 5 | 13–82.1 | 0.358 (95% CI, 0.178–0.561) | 94.2% (95% CI, 90–96.2%) | < 0.0001 | 5.229 (95% CI, – 3.173 to 13.631) |
| p = 0.142 | ||||||
| Abnormal TBIL at admission | 16 | 2.0–30.6 | 0.088 (95% CI, 0.055–0.128) | 92.1% (95% CI, 89.2–93.9%) | < 0.0001 | 3.183 (95% CI, 0.029–6.338) |
| p = 0.0482 | ||||||
| Abnormal ALB on admission | 16 | 2.2–80.6 | 0.398 (95% CI, 0.306–0.495) | 96.1% (95% CI, 95.2–96.8%) | < 0.0001 | 8.819 (95% CI, 2.302–15.335) |
| p = 0.0116 | ||||||
| Any abnormal liver biochemical indicator during hospitalization | 7 | 9.8–78.0 | 0.360 (95% CI, 0.118–0.648) | 99.2% (95% CI, 99–99.3%) | < 0.0001 | 7.738 (95% CI, – 13.782 to 29.258) |
| p = 0.3978 | ||||||
| Abnormal ALT during hospitalization | 5 | 14.1–54.7 | 0.384 (95% CI, 0.242–0.537) | 91.3% (95% CI, 82.5–94.6%) | < 0.0001 | – 0.620 (95% CI, – 14.725 to 13.486) |
| p = 0.8977 | ||||||
| Abnormal AST during hospitalization | 5 | 6.3–47.4 | 0.281 (95% CI, 0.159–0.422) | 90.6% (95% CI, 80.5–94.3%) | < 0.0001 | – 1.705 (95% CI, – 17.062 to 13.651) |
| p = 0.7471 | ||||||
| Abnormal TBIL during hospitalization | 3 | 3.9–48.9 | 0.232 (95% CI, 0.006–0.642) | 99.2% (95% CI, 98.9–99.3%) | < 0.0001 | NA |
| NA | ||||||
ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gammaglutamyltranspeptidase, TBIL total bilirubin, ALB albumin, NA not available, — the results cannot be calculated