Table 5.
Detection of the 4F-MDMB-BINACA metabolites after amide hydrolysis (MB1) or ester hydrolysis (MB8, metabolite IDs correspond to Table 1) in in vitro incubations containing one out of three human carboxylesterase isozymes (hCES), respectively, pooled human liver microsomes (pHLM), pooled human liver S9 fraction (pHLS9), or pooled human blood plasma (pHBP).
| Enzyme preparation | Metabolite ID | |
|---|---|---|
| MB1 | MB8 | |
| hCES1b | – | + |
| hCES1c | + | + |
| hCES2 | – | – |
| pHLM | + | + |
| pHLS9 | + | + |
| pHBP | – | – |
Incubations were performed in duplicate; +, detected; –, not detected.