Table 1.

Homo- and heterodimerization strengths for three of the studied RTKs

Shown are K_d and dimer stabilities (ΔG) for EGFR homodimers, EPHA2 homodimers, VEGFR2 homodimers, EGFR–EPHA2 heterodimers, EGFR–VEGFR2 heterodimers, and EPHA2–VEGFR2 heterodimers. Errors represent the 95% confidence interval from the fit. All values are for the ECTM versions of the receptors. Values for the EGFR and VEGFR2 homodimers have been measured previously (1, 77).

	Kd	ΔG
	receptors/μm2	kcal/mol
EGFR	2800 ± 200	−3.5 ± 0.1
EPHA2	860 ± 50	−4.0 ± 0.1
VEGFR2	2700 ± 450	−3.5 ± 0.1
EGFR–EPHA2	5000 ± 1000	−3.1 ± 0.2
EGFR–VEGFR2	5200 ± 1200	−3.1 ± 0.2
EPHA2–VEGFR2	2900 ± 900	−3.4 ± 0.2