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The three steps of the CYP51 reaction. *, lanosterol is the natural CYP51 substrate in vertebrates and in some yeasts. The other CYP51 substrates are 24,25-dihydrolanosterol, 24-methylene-dihydrolanosterol, C4-norlanosterol, and obtusifoliol. **, 3β-hydroxy-4,4-dimethyl-cholesta-8,14,24-triene. Examples of other P450s catalyzing multistep reactions are shown in Fig. S1.
