Table 3.
Upstream analysis of genes identified through microarray analysis of HUVEC treated with hydroxyurea.
| Upstream regulator | Molecule type | Predicted activation state | Activation z-sore | p-value of overlap |
|---|---|---|---|---|
| 15-deoxy-delta-12,14 -PGJ 2 | Chemical–endogenous non-mammalian | Inhibited | −2.125 | 1.00E00 |
| Pkc(s) | Group | Inhibited | −3.043 | 1.00E00 |
| Vegf | Group | Inhibited | −2.126 | 1.41E−02 |
| PRKAA2 | Kinase | Inhibited | −2.101 | 4.06E−03 |
| CD24 | Other | Inhibited | −4.459 | 5.89E−04 |
| GJA1 | Transporter | Inhibited | −2.190 | 2.56E−02 |
| FOXM1 | Transcription regulator | Inhibited | −2.242 | 1.40E−06 |
| FOXO1 | Transcription regulator | Inhibited | −2.628 | 2.12E−01 |
| S100A6 | Transporter | Inhibited | −2.345 | 1.42E−02 |
| YAP1 | Transcription regulator | Inhibited | −2.449 | 1.23E−02 |
| TCF4 | Transcription regulator | Inhibited | −2.252 | 2.59E−02 |
| OSM | Cytokine | Inhibited | −2.123 | 4.56E−01 |
| ESR1 | Ligand-dependent nuclear receptor | Inhibited | −2.662 | 3.28E−07 |
| Ellagic acid | Chemical–endogenous non-mammalian | Inhibited | −2.000 | 4.71E−02 |
| Imatinib | Chemical drug | Inhibited | −2.097 | 3.11E−01 |
| GW9662 | Chemical reagent | Inhibited | −2.055 | 2.31E−01 |
| Isoproterenol | Chemical drug | Inhibited | −2.789 | 3.52E−01 |
| Cholecalciferol | Chemical–endogenous mammalian | Inhibited | −2.331 | 1.00E00 |
| R-WIN 55,212 | Chemical reagent | Inhibited | −2.063 | 3.88E-04 |
| zVAD-FMK | Chemical–protease inhibitor | Inhibited | −2.000 | 1.36E-01 |
| Cocaine | Chemical drug | Inhibited | −2.193 | 1.00E00 |
| 25-hydroxycholesterol | Chemical reagent | Inhibited | −2.190 | 1.00E00 |
| Hyaluronic acid | Chemical–endogenous mammalian | Activated | 2.000 | 1.00E00 |
| E2f | Group | Activated | 2.725 | 8.25E−06 |
| SPDEF | Transcription regulator | Activated | 2.158 | 2.85E−01 |
| EPAS1 | Transcription regulator | Activated | 2.059 | 1.00E00 |
| SPI1 | Transcription regulator | Activated | 2.565 | 1.00E00 |
| miR-155-5p (miRNAs w/seed UAAUGCU) | Mature microRNA | Activated | 2.840 | 2.12E−01 |
| mir-15 | MicroRNA | Activated | 2.277 | 9.16E−02 |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | Mature microRNA | Activated | 2.255 | 4.19E−01 |
| miR-141-3p (and other miRNAs w/seed AACACUG) | Mature microRNA | Activated | 2.801 | 2.69E−02 |
| mir-145 | MicroRNA | Activated | 2.236 | 4.67E−01 |
| NUPR1 | Transcription regulator | Activated | 4.357 | 1.63E−05 |
| JUN | Transcription regulator | Activated | 2.560 | 1.00E00 |
| SRSF3 | Other | Activated | 2.229 | 1.78E−02 |
| KLF4 | transcription regulator | Activated | 2.020 | 1.00E00 |
| SYK | Kinase | Activated | 2.695 | 1.78E−01 |
| TBX5 | Transcription regulator | Activated | 2.000 | 1.00E00 |
| MEOX2 | Transcription regulator | Activated | 2.200 | 4.96E−01 |
| IFNB1 | Cytokine | Activated | 2.183 | 1.00E00 |
| IL15 | Cytokine | Activated | 2.280 | 1.00E00 |
| Sulindac sulfide | Chemical drug | Activated | 2.192 | 2.65E−01 |
| GW3965 | Chemical reagent | Activated | 2.204 | 1.00E00 |
| Mifepristone | Chemical drug | Activated | 2.201 | 3.74E−01 |