Skip to main content
. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: Nat Chem Biol. 2019 Apr 15;15(5):472–479. doi: 10.1038/s41589-019-0267-9

Figure 2. Structural features of Mango-III.

Figure 2.

(a) Hydrogen bonding interactions of the A7•U19•A25 base triple (purple) and the G-quadruplex T1(blue). Red and purple spheres, water molecule at the center of the triple (W1), and K+ at the center of the G-quadruplex (MA), respectively. (b) The base triple stacks under the G-quadruplex and above the duplex P1. (c) Hydrated metal ion modeled as Na+ (green sphere) bridging the coaxial junction. (d) View of P2 from the direction of the G21-U24 strand. Arrows denote 5’ to 3’ chain direction. (e) 180° rotation along the vertical axis. (f) The three non-canonical base pairs of P2.