Figure 3.

Safety of administering intravenous (IV) iron to hemodialysis patients by ferritin concentration (based on available evidence). Eligibility criteria for each of the cited studies differ and may affect generalizability of the results to broader populations. ∗Results of observational studies should be viewed cautiously because weaker associations may be attributable to confounding. Abbreviations: DRIVE, Dialysis Patients' Response to IV Iron with Elevated Ferritin; PIVOTAL, Proactive IV Iron Therapy in Haemodialysis Patients; RCT, randomized controlled trial.