Table 1.
Deliberate Delay of Definitive Treatment for Frankly Invasive Cervical Cancer
| Authors | Year | Stage | Patients (n) | Delay | Maternal Outcome |
|---|---|---|---|---|---|
| Prem et al. | 1966 | I | 4 | 6 wk | NED 5 yr |
| I | 5 | 11–17 wk | NED 3–5 yr | ||
| Dudan et al. | 1973 | IB | 2 | 2 and 6 mo | Progression |
| Lee et al. | 1981 | IB | 1 | 12 wk | NED 10 yr |
| IB | 2 | 11 wk | No progression | ||
| II | 5 | 1–11 wk | No progression | ||
| Nisker and Shubat | 1983 | IB | 1 | 24 wk | DOD |
| Greer et al. | 1989 | IB | 5 | 6–17 wk | NED 1–3 yr (n = 4), DOD (n = 1) |
| Monk and Montz | 1992 | IB | 4 | 10–16 wk | NED 3.5 yr |
| Hopkins and Morley | 1992 | IB | 5 | 12 wk | NED 5 yr (n = 40) |
| Mack et al. | 1981 | IB | 3 | 10–16 wk | NED |
| Duggan et al. | 1993 | IB1 | 5 | 7–24 wk | NED 3 yr |
| Sivanesaratnam et al | 1993 | IB | 2 | 2 and 4 wk | NED 5 yr |
| Allen et al. | 1995 | IB | 2 | 18–19 wk | NED 5 yr |
| Sorosky et al | 1995 | IB1 | 7 | 7–29 wk | NED 1.5–5.5 yr |
| Sood et al. | 1996 | IB | 3 | 3–32 wk | NED 1–30 yr |
| Tewari et al. | 1997 | IB2 | 1* | 11 wk | NED 2 yr |
| IIA | 1* | 18 wk | DOD 9 mo | ||
| van Vliet et al. | 1998 | IB | 5 | 2–10 wk | DOD (n = 1), NED 1.5–9 yr |
| IIA | 1 | 2 wk | NED 12 yr | ||
| Marana et al. | 2001 | IIB | 1* | 21 wk | DOD 18 mo* |
| Takushi et al. | 2002 | IB1 | 2 | 13 and 15 wk | NED 8 and 9 yr |
| IB2 | 1 | 6 wk | NED 7 yr | ||
| Germann et al. | 2005 | IB1 | 9 | 4 mo | NED 5 yr |
| Traen et al. | 2006 | IB1 | 1 | 19 wk | NED |
| Gonzalez Basquet et al. | 2008 | IB | 1 | 8 wk | NED 1 yr |
| Favero et al. | 2010 | IB1 | 10 | 11–28 wk | NED 5–102 mos |
| IB2 | 1 | 12 wk | NED 68 mos | ||
Modified from Tewari K, Cappuccini F, Gambino A, et al. Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy: a report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy. Cancer 1998;82:1529.