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Effect of napabucasin (BBI 608) on proliferation, and survival (A). The Br-dU assay shows that the napabucasin (BBI 608) treatment significantly decreases the CRC cell line proliferation in a dose dependent pattern. (B). Clonogenic evaluations indicate that the napabucasin or 5-FU combination with radiation (IR) treatment significantly decrease CRC cell line survival in a dose dependent (0GY to 6GY) pattern. (Results are showed as mean ± SD (***p<0.0001; NS, non-significant).
