Table 1.

Patient Characteristics

Characteristic	N=42
Age in years, median (IQR)	60 (56-71)
Female	28 (67%)
Smoking status
Never	3 (7%)
Former	36 (86%)
Current	3 (7%)
ECOG Performance Status
0	4 (10%)
1	38 (90%)
# lines prior systemic therapy
0	15 (36%)
1	14 (33%)
2+	13 (31%)
Prior local CNS therapy*
None	21 (50%)
Stereotactic radiosurgery	16 (38%)
Whole brain radiation therapy (WBRT)	8 (19%)
Craniotomy/resection	4 (10%)
Histology
Adenocarcinoma	36 (86%)
Squamous cell	4 (10%)
Poorly differentiated carcinoma	2 (5%)
Molecular alteration
KRAS	14 (33%)
EGFR	6 (14%)
ALK	1 (2%)
HER2	1 (2%)
MET exon 14	1 (2%)

^*Some patients received more than one treatment modality

IQR, interquartile range