Table 1.

Comparison of Clinical and Demographic Characteristics of 468 Patients With an IPAA in a Multicenter Cohort, Evaluated by a History of Pouch-Related Disorder

	No Pouchitis (n = 86)		Acute Pouchitis (n = 94)			Chronic Pouchitis (n = 96)			CD of the Pouch (n = 192)
	Median	IQR	Median	IQR	P vs No Pouchitis	Median	IQR	P vs No Pouchitis	Median	IQR	P vs No Pouchitis
Age at baseline visit	36	27–52	41	32–50	0.141	46	33–57	0.024	41	32–51	0.083
Age at colectomy	31	24–44	32	21–43	0.377	34	26–48	0.260	28	22–41	0.024
Duration between colectomy and baseline visit	2	0.4–5	7	3–12	<0.001	7	3–14	<0.001	10	4–17	<0.001
Modified Pouchitis Disease Activity Index at enrollmenta	1	0–2	3	2–4	<0.001	3	1–4	<0.001	3	1–5	<0.001
	n	%	n	%		n	%		n	%
Female sex	38	45	42	45	0.997	45	47	0.770	108	58	0.046
Race					0.015			0.067			0.589
White	74	87	91	97		91	95		167	89
Non-white	11	13	3	3		5	5		20	11
Colonic dysplasia at the time of colectomy	15	19	8	9	0.070	10	11	0.171	7	4	<0.001
Technique used in IPAAb					0.584			0.630			0.531
Hand-sewn	9	19	7	15		12	29		19	23
Stapled	39	81	41	85		41	77		62	77
Any history of smoking cigarettes	17	21	32	31	1.000	31	33	0.597	65	35	0.459
History of extraintestinal manifestationc	16	19	23	25	0.340	28	29	0.097	74	39	0.001
History of primary sclerosing cholangitis	8	10	3	3	0.076	12	13	0.512	7	4	0.054

IQR, interquartile range.

^aThree hundred two patients had available data for all components of the modified pouchitis disease activity index at the enrollment visit.

^bData regarding type of anastomosis available for 236 patients.

^cExtraintestinal manifestation defined as ankylosing spondylitis, arthritis (small or large joints), episcleritis/scleritis, erythema nodosum, oral ulcers, pyoderma gangrenosum, sacroiliitis, or uveitis/iritis.