Table 3: Allergic Clinical Characteristics associated with Grade 2/3 allergic reaction during Almond Challenge.

OR for specific IgE represent the increased odds for every 10 kU/L change in IgE. OR for SPT represent the increased odds for every 5 mm change in wheal. Variables not meeting significance criteria were excluded from the table.

	No Grade 2/3 symptoms (n=569)	Grade 2/3 N-B reaction (n= 21)	Unadj. OR [95% CI]	p	Adj. OR [95% CI]	p
Demographics
Age at challenge in years, mean (sd)	10.4 (8.2)	6.1 (3.4)	0.86 [0.77, 0.97]	0.01	0.85 [0.75, 0.97]	0.01
Almond History
Almond-specific IgE, mean (sd)	3.1 (7.7)	14.3 (27.3)	1.51 [1.22, 1.87]	<0.001	1.25 [0.96, 1.64]	0.10
Almond SPT in mm, mean (sd)	3.8 (3.6)	7.8 (5.8)	2.75 [1.69, 4.47]	<0.001	2.57 [1.47, 4.47]	<0.001
Allergic Sensitization
Peanut IgE, mean (sd)	26.9 (37.1)	52.8 (49.3)	1.16 [1.04, 1.29]	0.006	-	-
Pistachio IgE, mean (sd)	10.5 (20.6)	21.2 (32.5)	1.17 [1.01, 1.36]	0.044	-	-
Pecan IgE, mean (sd)	5.1 (13.2)	12.0 (22.8)	1.24 [1.01, 1.52]	0.048	-	-
Walnut IgE, mean (sd)	10.4 (22.4)	23.1 (41.0)	1.16 [1.02, 1.33]	0.028	-	-